Mutants Resistant to LpxC Inhibitors by Rebalancing Cellular Homeostasis*
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چکیده
منابع مشابه
Mutants resistant to LpxC inhibitors by rebalancing cellular homeostasis.
LpxC, the deacetylase that catalyzes the second and committed step of lipid A biosynthesis in Escherichia coli, is an essential enzyme in virtually all gram-negative bacteria and is one of the most promising antibiotic targets for treatment of multidrug-resistant gram-negative infections. Despite the rapid development of LpxC-targeting antibiotics, the potential mechanisms of bacterial resistan...
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Characterization of LpxC Inhibitors and Resistant Mutants by Daina Zeng Department of Biochemistry Duke University Date:_______________________ Approved: ___________________________ Pei Zhou, Supervisor ___________________________ Michael D. Been ___________________________ Kenneth N. Kreuzer ___________________________ Raphael H. Valdivia ___________________________ Robert A. Nicholas An abstr...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2013
ISSN: 0021-9258
DOI: 10.1074/jbc.m112.447607